In Terror Train 2, it has been over a year since a series of gruesome, vengeful murders took the lives of multiple college seniors aboard the now infamous Terror Train. Alana (Robyn Alomar) is coerced to join The Magician (Tim Rozon) and other remaining survivors on a New Year's Eve redemption ride aboard the very same train, where a new kind of evil spawns a vengeful bloodbath and once again, the terrified passengers fight survive.

　　It follows a college student as she boards a party train for Halloween, and ends up fighting for her life when a mysterious assailant begins killing the people one-by-one.